In Silico Approach For Detection Of The Effect Of UGT1A1 Polymorphisms On Telmisartan Response

Hypertension is a cardiovascular disease that manifests itself with continuous increase in systemic arterial blood pressure and can lead to serious complications over time. It estimated 37% of hypertensive patients receive treatment one-third them are under control. Telmisartan an angiotensin receptor blocker used the hypertension. Uridine 5'-diphospho-glucuronyltransferase 1 (UGT1A1) gene encodes (UGT) enzyme metabolizes telmisartan. Single nucleotide polymorphisms cause amino acid, protein structure, function change. These changes affect drug response therapy. Polymorphisms UGT1A1 (rs4148323, rs28934877) telmisartan resistance. In this study, SWISS-MODEL database Chimera 1.15 ver. Programs were create homology models. The HOPE was calculate damage mutation on structure show effects protein. HDock server demonstrate interactions between wild-type and, mutant type detected residue (rs4148323) located important domain for activity. Mutation might disturb function. rs28934877 probably damaging mutations loss response. By docking analysis, shown wild types Possible conformation designed effective carrying common mutation.